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Adalimumab (Humira)—Ototoxic or Not?

by Neil Bauman, Ph.D.

A man wrote:

I started taking Adalimumab (Humira) 40 mg in April 2007. Approximately 4 weeks after the first shot, I started having severe vertigo and dizziness along with tinnitus. My balance has been an issue ever since. I have visited and asked several doctors including my primary care physicians, my rheumatologists, 2 otolaryngologists, 2 neurologists, and a neuro-otolaryngologist. I have also had a million dollar work up so they say. I have asked each an every one of these doctors if Humira would cause these symptoms, and each one has informed me that it would not. After taking injections for 17 months I decided to stop taking the injections in October of 2008. Since stopping the injections the symptoms have gradually subsided. I am not completely free of the symptoms and have reached a plateau. Was the Humira causing my balance problems and tinnitus? Will these symptoms ever go away?

I see no reason to doubt that the Humira was causing your balance problems and tinnitus. Although not reported in the PDR, there are other sources that list dizziness, vertigo and tinnitus as side effects of Adalimumab. So it spite of all your doctors to the contrary, Humira could indeed have caused the symptoms you have.

The proof that the Humira caused your tinnitus and balance problems is that they began after you started taking the Hurira, and then later when you stopped taking the Humira, your symptoms began to go away.

I do not have any information on whether the damage will be permanent or not. However, obviously, to some extent your side effects are temporary as your symptoms are slowly going away. We can hope that eventually all your symptoms will disappear, but I do not know if that is realistic to expect or not. You may find some permanent damage remains.

To learn which drugs are (or can be) ototoxic, see “Ototoxic Drugs Exposed“. This book contains information on the ototoxicity of 877 drugs, 35 herbs and 148 chemicals.

Reader Interactions

Comments

  1. Janet Buckley says

    May 20, 2011 at 4:16 PM

    I have injected Humira for two years, and experiencing severe skin/nerve sensitivities. When I touch my skin around waist and buttocks, it feels like needles is piercing the skin and a burning sensation. I am now experiencing migraine headaches, which is causing blurred vision and eyes hurt and feels thick. I feel dizzy and at times afraid I might pass out. My heart feels racing. I feel tired all the time, and can’t get enough sleep. My moods are very low and think of death alot. Humira does help the RA, but these side effects are much more than my body can tolerate. I’ve talked to my Rhumy, and his solution is to start infusions, which I’m scared to do that now. He really has no answers for me. It has been six months dealing with these forever ongoing symptoms, and I’m afraid to give my next injection as I don’t believe I will survive it.

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Neil G. Bauman, Ph.D.

1013 Ridgeway Drive, Lynden,
WA 98264-1057 USA

Email: neil@hearinglosshelp.com

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"The wages of sin is death, but the gift of God is eternal life [which also includes perfect hearing] through Jesus Christ our Lord." [Romans 6:23]

"But know this, in the last days perilous times will come" [2 Timothy 3:1]. "For there will be famines, pestilences, and [severe] earthquakes in various places" [Matthew 24:7], "distress of nations, the sea and the waves roaring"—tsunamis, hurricanes—Luke 21:25, but this is good news if you have put your trust in the Lord Jesus Christ, for "when these things begin to happen, lift up your heads [and rejoice] because your redemption draws near" [Luke 21:28].